"neurologic complications in hemophilia: a study in 214 cases "

intracranial hemorrhage and entrapment neuropathy are the most serious and disabling complications in hemophilia.the occurance of these neurological complications was studied in 214 hemophiliac patients during a 3 month period. nine patients (4.2%) suffered intracranial hemorrhage (one epidural and others intracerebral). all of intracranial hemorrhage patients had the sevee form of disease (<1% factor viii or ix). 6 out of 9 intracranial hemorrhage cases mentioned a history of head trauma. entrapment neuropathy was presen in 10 patients (femoral neuropathy 5, ulnar n. 3, radial n. 1 median n. 1) all of entropament neuropathy patients described a history of trauma to the extremities. eight patients in the latter group had severe disease and two patients had moderate disease (1-5%). the proportion of intracranial hemorrhage following head trauma (20% in this series) was greater than other studies. in conclusion, early diagnostic evaluation and replacement therapy may be beneficial in hemophilic patients with trauma.